The bank has made major lay-offs in institutional and retail equity sales and structuring in the region, amid whispers it plans to shut its equities and corporate finance units globally.
The job losses are primarily in Hong Kong and Singapore where most of the Swiss firm's private bankers are located.
Australia''s largest bank closes its institutional markets offices in Singapore, Korea and Malaysia, as well as its Tokyo-based securities company.
Andrew Kwek steps down at the end of this month.
A round of senior level cuts has begun.
Asia Online cuts jobs, units to help move towards profits.